eComment: Statins and ACE-inhibitors

eComment: Statins and ACE-inhibitors.

ACE, ACE inhibitors, and other JNK.

The renin-angiotensin system (RAS) plays a pivotal role in the regulation of blood pressure, volume homeostasis, vascular function, and cell growth. In what is considered the classic RAS, renin is released from juxtaglomerular cells of the kidney into the circulation where it converts angiotensinogen from the liver to angiotensin I. Angiotensin I is subsequently hydrolyzed by a peptidyl dipepti...

ACE inhibitors and anaesthesia.

During the last decade, two angiotensin converting enzyme (ACE) inhibitors, captopril and enalapril, have become accepted into clinical practice and are regarded as effective treatments for hypertension and congestive cardiac failure.' A third agent, lisinopril, had recently become available and others are likely to be introduced in the near future. It is clear, therefore, that more patients, w...

ACE inhibitors and statins acutely improve endothelial dysfunction of human coronary arterioles.

Long-term treatment with angiotensin-converting enzyme (ACE) inhibitors as well as angiotensin II type 1 (AT(1)) receptor antagonists and statins reduces cardiovascular mortality in patients with coronary artery disease as well as chronic heart failure. Little is known about the acute effects of these compounds on vascular reactivity of coronary resistance vessels. Coronary arterioles were obta...

Impact of statins and ACE inhibitors on mortality after COPD exacerbations

BACKGROUND The purpose of our study was to examine the association of prior outpatient use of statins and angiotensin converting enzyme (ACE) inhibitors on mortality for subjects >or= 65 years of age hospitalized with acute COPD exacerbations. METHODS We conducted a retrospective national cohort study using Veterans Affairs administrative data including subjects >or=65 years of age hospitaliz...